msh-6

Caenorhabditis elegans

Predicted to enable four-way junction DNA binding activity and mismatched DNA binding activity. Involved in maintenance of DNA repeat elements and mismatch repair. Predicted to be located in nucleus. Predicted to be part of MutSalpha complex. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in several diseases, including colorectal carcinoma; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Is an ortholog of human MSH6 (mutS homolog 6).

msh-4

Caenorhabditis elegans

Enriched in Z1.p; Z4.a; germline precursor cell; gon_male_dtc anterior; and gon_male_dtc posterior based on RNA-seq studies. Is affected by several genes including cyc-1; mut-16; and mrps-5 based on microarray and RNA-seq studies. Is affected by seven chemicals including metformin; Sirolimus; and rifampin based on RNA-seq and microarray studies.

msh-5

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity. Involved in chiasma assembly. Located in nucleus. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; primary ovarian insufficiency 13; and spermatogenic failure. Is an ortholog of human MSH5 (mutS homolog 5).

ubxn-6

Caenorhabditis elegans

Predicted to be located in cytoplasm. Expressed in pharynx. Is an ortholog of human UBXN6 (UBX domain protein 6).

Y57G11C.3

Caenorhabditis elegans

Predicted to enable 6-phosphogluconolactonase activity. Predicted to be involved in pentose-phosphate shunt, oxidative branch. Located in nucleus. Expressed in germ cell. Is an ortholog of human PGLS (6-phosphogluconolactonase).

such-6

Caenorhabditis elegans

vab-15

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic morphogenesis; locomotory behavior; and parturition. Located in nucleus. Expressed in several structures, including P1; P12; P2; neuroblasts; and neurons. Human ortholog(s) of this gene implicated in several diseases, including cleft lip; orofacial cleft 5; and tooth disease (multiple). Is an ortholog of human MSX1 (msh homeobox 1).

cdr-6

Caenorhabditis elegans

Predicted to be located in cytoplasm.

mau-6

Caenorhabditis elegans

sul-1

Caenorhabditis elegans

Enables heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification. Predicted to be located in Golgi stack; cell surface; and endoplasmic reticulum. Is an ortholog of human SULF1 (sulfatase 1) and SULF2 (sulfatase 2).