Enables MAP kinase activity. Involved in several processes, including determination of adult lifespan; intracellular signaling cassette; and positive regulation of macromolecule metabolic process. Located in cytoplasm and nucleus. Expressed in F cell; U cell; germ line; gonad; and oocyte. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Noonan syndrome 13; carcinoma (multiple); and childhood pilocytic astrocytoma. Is an ortholog of human MAPK1 (mitogen-activated protein kinase 1).
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in prostate cancer. Is an ortholog of human MAPK7 (mitogen-activated protein kinase 7).
Enables mitogen-activated protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of endocytic recycling; regulation of Golgi organization; and regulation of oocyte development. Located in cytoplasm and cytoplasmic side of apical plasma membrane. Used to study cerebral cavernous malformation. Is an ortholog of human STK26 (serine/threonine kinase 26).
Enriched in neurons based on RNA-seq studies. Is affected by kri-1 and mpk-2 based on RNA-seq studies. Is affected by Tunicamycin and Cadmium Chloride based on RNA-seq studies.
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in meiotic chromosome segregation and positive regulation of meiotic cell cycle. Predicted to be located in nucleus. Expressed in gonad.
Is affected by several genes including hpl-2; dpy-21; and mpk-2 based on tiling array; microarray; and RNA-seq studies. Is predicted to encode a protein with the following domains: Peptidase C14A; SPK domain; and Domain of unknown function (DUF545).