mod-1

Caenorhabditis elegans

Enables serotonin binding activity and serotonin-gated chloride channel activity. Involved in several processes, including behavioral response to starvation; locomotory exploration behavior; and positive regulation of fatty acid beta-oxidation by serotonin receptor signaling pathway. Located in neuronal cell body and plasma membrane. Expressed in body wall musculature and neurons. Used to study cocaine abuse.

mod-5

Caenorhabditis elegans

Enables serotonin:sodium:chloride symporter activity. Involved in serotonin uptake. Predicted to be located in neuron projection; plasma membrane; and synapse. Expressed in several structures, including nerve ring. Used to study cocaine abuse. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; and alexithymia. Is an ortholog of human SLC6A4 (solute carrier family 6 member 4).

ser-1

Caenorhabditis elegans

Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in several processes, including reproductive behavior; response to heat; and signal transduction. Located in plasma membrane. Expressed in several structures, including egg-laying apparatus; intestine; neurons; pharyngeal muscle cell; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcoholic psychosis; and metabolic dysfunction-associated steatotic liver disease (multiple). Is an ortholog of human HTR2A (5-hydroxytryptamine receptor 2A) and HTR2B (5-hydroxytryptamine receptor 2B).