mlc-5

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Involved in mitotic cytokinesis. Located in actin cytoskeleton. Human ortholog(s) of this gene implicated in congenital myopathy 14; familial atrial fibrillation; and hypertrophic cardiomyopathy 8. Is an ortholog of human MYL4 (myosin light chain 4); MYL6 (myosin light chain 6); and MYL6B (myosin light chain 6B).

mlc-2

Caenorhabditis elegans

Predicted to enable myosin heavy chain binding activity. Involved in several processes, including nematode larval development; regulation of muscle contraction; and regulation of nematode pharyngeal pumping. Predicted to be located in cytoplasm. Predicted to be part of myosin II complex. Expressed in body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7).

mlc-4

Caenorhabditis elegans

Predicted to enable myosin heavy chain binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; embryonic body morphogenesis; and nematode larval development. Located in cytoplasm. Part of filamentous actin. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and megacystis-microcolon-intestinal hypoperistalsis syndrome. Is an ortholog of human MYL9 (myosin light chain 9).

mlc-3

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Located in striated muscle myosin thick filament. Expressed in head neurons; nervous system; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 8. Is an ortholog of human MYL3 (myosin light chain 3) and MYL6B (myosin light chain 6B).

mlc-1

Caenorhabditis elegans

Predicted to enable myosin heavy chain binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7).

cow-1

Caenorhabditis elegans

mrck-1

Caenorhabditis elegans

Enables myosin light chain kinase activity. Involved in several processes, including embryonic body morphogenesis; positive regulation of endocytic recycling; and regulation of Golgi organization. Located in cytoplasm. Expressed in Ea and Ep. Used to study cerebral cavernous malformation. Is an ortholog of human CDC42BPA (CDC42 binding protein kinase alpha) and CDC42BPB (CDC42 binding protein kinase beta).

nmy-1

Caenorhabditis elegans

Predicted to enable actin filament binding activity and microfilament motor activity. Involved in several processes, including locomotion; nematode larval development; and regulation of embryonic cell shape. Located in adherens junction and contractile muscle fiber. Expressed in head; hypodermis; and tail. Human ortholog(s) of this gene implicated in several diseases, including aortic aneurysm (multiple); auditory system disease (multiple); and blood platelet disease (multiple). Is an ortholog of human MYH11 (myosin heavy chain 11).

mig-17

Caenorhabditis elegans

Enables metallopeptidase activity. Involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration. Located in basement membrane and extracellular space. Expressed in several structures, including body wall musculature; gonad; head; intestine; and ventral nerve cord.