daf-12

Caenorhabditis elegans

Enables nuclear receptor activity; sequence-specific DNA binding activity; and steroid hormone binding activity. Involved in several processes, including determination of adult lifespan; heat acclimation; and positive regulation of dauer larval development. Located in nucleus. Expressed in several structures, including gonad; neurons; pharyngeal muscle cell; somatic gonad precursor; and vulva. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); autosomal recessive limb-girdle muscular dystrophy type 2B; and carcinoma (multiple). Is an ortholog of human VDR (vitamin D receptor).

mig-20

Caenorhabditis elegans

mig-23

Caenorhabditis elegans

Enables ADP phosphatase activity; GDP phosphatase activity; and UDP phosphatase activity. Involved in several processes, including gonad morphogenesis; positive regulation of protein glycosylation; and ribonucleoside diphosphate catabolic process. Located in cytoplasm. Expressed in head and tail. Is an ortholog of human ENTPD4 (ectonucleoside triphosphate diphosphohydrolase 4) and ENTPD7 (ectonucleoside triphosphate diphosphohydrolase 7).

mig-12

Caenorhabditis elegans

mig-4

Caenorhabditis elegans

mig-6

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Involved in several processes, including anatomical structure morphogenesis; distal tip cell migration; and nematode larval development. Located in basement membrane. Expressed in several structures, including CAN; GLR; basal lamina; enteric muscle; and somatic gonad precursor. Is an ortholog of human PAPLN (papilin, proteoglycan like sulfated glycoprotein).

mig-17

Caenorhabditis elegans

Enables metallopeptidase activity. Involved in several processes, including gonad morphogenesis; protein processing; and regulation of distal tip cell migration. Located in basement membrane and extracellular space. Expressed in several structures, including body wall musculature; gonad; head; intestine; and ventral nerve cord.

mig-32

Caenorhabditis elegans

Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of vulval development; nematode male tail tip morphogenesis; and regulation of axon extension involved in axon guidance. Located in nucleolus. Expressed in several structures, including germ line and ventral ganglion. Is an ortholog of human PCGF3 (polycomb group ring finger 3).

mig-13

Caenorhabditis elegans

Involved in positive regulation of cell migration. Located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including QR.a; QR.p; QR.pa; body ganglion; and somatic neurons.

mig-15

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase).