Enables histone H3K36 methyltransferase activity. Involved in germ-line sex determination and heterochromatin formation. Acts upstream of or within with a positive effect on dosage compensation by hypoactivation of X chromosome. Located in X chromosome; autosome; and nuclear chromosome. Part of chromatin. Expressed in Z2; Z3; and germ line. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 1; lung non-small cell carcinoma; and neuroblastoma. Is an ortholog of human NSD1 (nuclear receptor binding SET domain protein 1); NSD2 (nuclear receptor binding SET domain protein 2); and NSD3 (nuclear receptor binding SET domain protein 3).
Predicted to contribute to nucleosome binding activity. Involved in regulation of gene expression. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; intestinal cell; and oocyte. Is an ortholog of human EED (embryonic ectoderm development).
Involved in regulation of gene expression. Located in nucleus. Part of PcG protein complex and nucleosome. Expressed in several structures, including Caa; Psub4; Z2; Z3; and germ line.
Enables histone H3K27 methyltransferase activity. Involved in epigenetic regulation of gene expression; germ-line stem cell division; and tissue development. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; hypodermis; and intestine. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); and respiratory system cancer (multiple). Is an ortholog of human EZH1 (enhancer of zeste 1 polycomb repressive complex 2 subunit) and EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit).
Enriched in ASEL; ASER; and neurons based on RNA-seq and single-cell RNA-seq studies. Is affected by adr-1; mes-4; and ogt-1 based on RNA-seq studies. Is affected by tryptophan based on microarray studies.
Enriched in ASER based on RNA-seq studies. Is affected by mes-4 and mrg-1 based on RNA-seq studies. Is predicted to encode a protein with the following domains: Regulatory Factors in Gene Expression and Cell Death and Zinc finger C2H2-type.
Predicted to enable glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity. Predicted to be located in membrane. Expressed in intestine; pharynx; and seam cell.
Enriched in M cell; dorso-rectal ganglion; and neurons based on single-cell RNA-seq and RNA-seq studies. Is affected by several genes including dpy-21; ins-11; and unc-4 based on RNA-seq studies. Is affected by antimycin based on RNA-seq studies.
Enriched in M cell based on single-cell RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and mter-4 based on microarray and RNA-seq studies. Is affected by five chemicals including D-glucose; Psoralens; and allantoin based on RNA-seq and microarray studies.