top-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable DNA binding activity; DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; and small molecule binding activity. Involved in mitotic sister chromatid separation. Predicted to be located in nucleus. Expressed in embryonic cell; germ cell; and somatic cell. Human ortholog(s) of this gene implicated in several diseases, including cervix uteri carcinoma in situ; penile benign neoplasm; and urinary system cancer (multiple). Is an ortholog of human TOP2B (DNA topoisomerase II beta).