F47G4.5

Caenorhabditis elegans

Contributes to microtubule severing ATPase activity. Involved in microtubule depolymerization. Part of katanin complex. Expressed in amphid neurons; inner labial neurons; outer labial neurons; and phasmid neurons.

mei-1

Caenorhabditis elegans

Enables several functions, including ATP binding activity; MATH domain binding activity; and microtubule severing ATPase activity. Involved in several processes, including cytoskeleton organization; female meiotic nuclear division; and negative regulation of meiotic spindle elongation. Located in meiotic spindle pole and nucleus. Part of chromatin and katanin complex. Expressed in ciliated neurons; germ line; and head neurons. Is an ortholog of human KATNA1 (katanin catalytic subunit A1) and KATNAL1 (katanin catalytic subunit A1 like 1).

F47G4.4

Caenorhabditis elegans

Contributes to microtubule severing ATPase activity. Involved in microtubule depolymerization. Part of katanin complex. Human ortholog(s) of this gene implicated in lissencephaly 6. Is an ortholog of human KATNB1 (katanin regulatory subunit B1).

mei-2

Caenorhabditis elegans

Contributes to microtubule severing ATPase activity. Involved in embryo development; meiotic spindle organization; and microtubule depolymerization. Located in cytoplasm; nucleus; and spindle pole. Part of katanin complex.

cul-3

Caenorhabditis elegans

Enables POZ domain binding activity. Involved in cell development; protein catabolic process; and protein polyubiquitination. Part of Cul3-RING ubiquitin ligase complex. Expressed in head; linker cell; and tail. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Is an ortholog of human CUL3 (cullin 3).

csn-3

Caenorhabditis elegans

Involved in establishment of mitotic spindle localization; mitotic cytokinesis; and ubiquitin-dependent protein catabolic process. Part of COP9 signalosome. Is an ortholog of human COPS3 (COP9 signalosome subunit 3).

egg-3

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in cortical actin cytoskeleton organization; female gamete generation; and positive regulation of protein localization to cell cortex. Located in cell cortex.

dcn-1

Caenorhabditis elegans

Enables ubiquitin binding activity. Involved in microtubule cytoskeleton organization; protein catabolic process; and protein neddylation. Located in cytoplasm and nucleus. Is an ortholog of human DCUN1D1 (defective in cullin neddylation 1 domain containing 1) and DCUN1D2 (defective in cullin neddylation 1 domain containing 2).

ppfr-1

Caenorhabditis elegans

Enables protein domain specific binding activity and protein phosphatase activator activity. Involved in several processes, including establishment of mitotic spindle orientation; polar body extrusion after meiotic divisions; and regulation of spindle elongation. Located in cytoplasm. Expressed in several structures, including intestine; neurons; pharynx; ventral nerve cord; and vulval muscle. Is an ortholog of human PPP4R1 (protein phosphatase 4 regulatory subunit 1).

ZK909.3

Caenorhabditis elegans

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Is an ortholog of human HDDC3 (HD domain containing 3).