Predicted to enable transcription coactivator activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and negative regulation of vulval development. Located in nucleus. Expressed in several structures, including hypodermal cell; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); major depressive disorder; and phobic disorder. Is an ortholog of human MED12L (mediator complex subunit 12L).
Involved in lateral inhibition; positive regulation of Notch signaling pathway; and regulation of cell fate specification. Predicted to be located in nucleus. Predicted to be part of mediator complex. Expressed in body wall musculature.
Enables nuclear receptor binding activity and transcription coactivator activity. Involved in several processes, including determination of adult lifespan; regulation of primary metabolic process; and sequestering of triglyceride. Predicted to be located in nucleus. Expressed in head. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in schizophrenia. Is an ortholog of human MED15 (mediator complex subunit 15).
Predicted to enable transcription coactivator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is an ortholog of human MED6 (mediator complex subunit 6).