mbk-2

Caenorhabditis elegans

Enables protein serine/threonine kinase activity and protein tyrosine kinase activity. Involved in several processes, including P granule disassembly; asymmetric protein localization involved in cell fate determination; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in cell cortex and intracellular non-membrane-bounded organelle. Expressed in several structures, including body wall musculature; embryonic cell; gonad; oocyte; and pharynx. Used to study Down syndrome. Is an ortholog of human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) and DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3).

egg-3

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in cortical actin cytoskeleton organization; female gamete generation; and positive regulation of protein localization to cell cortex. Located in cell cortex.

egg-4

Caenorhabditis elegans

Enables protein kinase binding activity and protein kinase inhibitor activity. Involved in cortical actin cytoskeleton organization; female gamete generation; and positive regulation of protein localization to cell cortex. Located in cell cortex and nucleus. Expressed in germ line and oocyte. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Is an ortholog of human PTPRG (protein tyrosine phosphatase receptor type G) and PTPRZ1 (protein tyrosine phosphatase receptor type Z1).

trpp-11

Caenorhabditis elegans

Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2S. Is an ortholog of human TRAPPC11 (trafficking protein particle complex subunit 11).

cisd-3.2

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in mitochondrion. Is an ortholog of human CISD3 (CDGSH iron sulfur domain 3).

cisd-3.1

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in protein maturation by [2Fe-2S] cluster transfer. Predicted to be located in mitochondrion. Is an ortholog of human CISD3 (CDGSH iron sulfur domain 3).

egg-5

Caenorhabditis elegans

Enables protein kinase binding activity. Involved in cortical actin cytoskeleton organization; female gamete generation; and positive regulation of protein localization to cell cortex. Located in cell cortex and nucleus. Expressed in oocyte. Human ortholog(s) of this gene implicated in gastric adenocarcinoma. Is an ortholog of human PTPRG (protein tyrosine phosphatase receptor type G) and PTPRZ1 (protein tyrosine phosphatase receptor type Z1).

dnj-15

Caenorhabditis elegans

Predicted to enable ATPase activator activity and protein-folding chaperone binding activity. Predicted to be involved in [2Fe-2S] cluster assembly. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in sideroblastic anemia. Is an ortholog of human HSCB (HscB mitochondrial iron-sulfur cluster cochaperone).

mbk-1

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in several structures, including anterior gonad arm. Used to study Down syndrome and intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal obesity-metabolic syndrome 3; and autosomal dominant intellectual developmental disorder 7. Is an ortholog of human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A).

Y106G6D.5

Caenorhabditis elegans

Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be located in nuclear body. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2S and autosomal recessive distal hereditary motor neuronopathy 1. Is an ortholog of human IGHMBP2 (immunoglobulin mu DNA binding protein 2).