unc-71

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Expressed in several structures, including buccal cavity; excretory system; nerve ring; neuronal sheath cell; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Is an ortholog of human ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23).

max-2

Caenorhabditis elegans

Enables mitogen-activated protein kinase kinase kinase binding activity; protein serine/threonine kinase activity; and small GTPase binding activity. Involved in several processes, including gonad morphogenesis; inductive cell migration; and signal transduction. Predicted to be located in cytoplasm. Expressed in neurons; pharynx; and ventral nerve cord.

max-4

Caenorhabditis elegans

max-1

Caenorhabditis elegans

Involved in motor neuron axon guidance. Predicted to be located in cytoskeleton. Expressed in neurons. Is an ortholog of human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2).

max-6

Caenorhabditis elegans

mxl-1

Caenorhabditis elegans

Enables protein domain specific binding activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan. Located in nucleus. Part of transcription regulator complex. Expressed in tail neurons. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is an ortholog of human MAX (MYC associated factor X).

mdl-1

Caenorhabditis elegans

Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan and regulation of cell differentiation. Located in nucleus. Part of transcription regulator complex. Expressed in body wall musculature; neurons; pharynx; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Is an ortholog of human MXI1 (MAX interactor 1, dimerization protein).

mxl-3

Caenorhabditis elegans

Enables DNA-binding transcription factor activity and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of fatty acid biosynthetic process; and response to food. Acts upstream of with a positive effect on insulin receptor signaling pathway. Located in cytoplasm and nucleus. Expressed in AWCL; AWCR; neurons; and pharynx. Used to study diabetes mellitus. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is an ortholog of human MAX (MYC associated factor X).

mxl-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in determination of adult lifespan. Acts upstream of or within negative regulation of gene expression. Located in cytoplasm and nucleus. Expressed in hypodermis and intestine. Human ortholog(s) of this gene implicated in Takayasu's arteritis. Is an ortholog of human MLX (MAX dimerization protein MLX).

ZK909.3

Caenorhabditis elegans

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Is an ortholog of human HDDC3 (HD domain containing 3).