madd-4

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in dorsal/ventral axon guidance and synapse organization. Located in extracellular space. Expressed in blast cell; coelomocyte; neurons; and somatic nervous system. Is an ortholog of human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); ADAMTSL1 (ADAMTS like 1); and ADAMTSL3 (ADAMTS like 3).

ciao-1

Caenorhabditis elegans

Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human CIAO1 (cytosolic iron-sulfur assembly component 1).

madd-2

Caenorhabditis elegans

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).

ciao-2B

Caenorhabditis elegans

Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human CIAO2B (cytosolic iron-sulfur assembly component 2B).

Y105E8A.11

Caenorhabditis elegans

Predicted to be involved in protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in mitochondrial matrix. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 2. Is an ortholog of human BOLA3 (bolA family member 3).

mms-19

Caenorhabditis elegans

Predicted to be involved in protein maturation by iron-sulfur cluster transfer. Predicted to be located in cytoplasm; nucleus; and spindle. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human MMS19 (MMS19 homolog, cytosolic iron-sulfur assembly component).

oxy-4

Caenorhabditis elegans

Predicted to enable 4 iron, 4 sulfur cluster binding activity and metal ion binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to be part of cytosolic [4Fe-4S] assembly targeting complex. Is an ortholog of human CIAO3 (cytosolic iron-sulfur assembly component 3).

aex-3

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of digestive system process. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).

Y54G11A.9

Caenorhabditis elegans

Predicted to enable 2 iron, 2 sulfur cluster binding activity; 4 iron, 4 sulfur cluster binding activity; and iron ion binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by [4Fe-4S] cluster transfer. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 4. Is an ortholog of human ISCA2 (iron-sulfur cluster assembly 2).