madd-4

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in dorsal/ventral axon guidance and synapse organization. Located in extracellular space. Expressed in blast cell; coelomocyte; neurons; and somatic nervous system. Is an ortholog of human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); ADAMTSL1 (ADAMTS like 1); and ADAMTSL3 (ADAMTS like 3).

madd-2

Caenorhabditis elegans

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).

ndfl-4

Caenorhabditis elegans

Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in proton transmembrane transport. Predicted to be located in mitochondrial membrane. Predicted to be part of respiratory chain complex I.

aex-3

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of digestive system process. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).

plx-2

Caenorhabditis elegans

Enables semaphorin receptor activity. Involved in several processes, including axonal fasciculation; nematode larval development; and nematode male tail tip morphogenesis. Located in cell leading edge and cell surface. Expressed in several structures, including P3/4L; P9/10L; P9/10R; neuroblasts; and ray structural cell.