madd-4

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in dorsal/ventral axon guidance and synapse organization. Located in extracellular space. Expressed in blast cell; coelomocyte; neurons; and somatic nervous system. Is an ortholog of human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); ADAMTSL1 (ADAMTS like 1); and ADAMTSL3 (ADAMTS like 3).

vps-32.1

Caenorhabditis elegans

Predicted to be involved in late endosome to vacuole transport via multivesicular body sorting pathway and vesicle budding from membrane. Located in endosome membrane. Expressed in gonad; neurons; and vulva. Human ortholog(s) of this gene implicated in cataract 31 multiple types. Is an ortholog of human CHMP4B (charged multivesicular body protein 4B) and CHMP4BP1 (charged multivesicular body protein 4B pseudogene 1).

F07C6.4

Caenorhabditis elegans

Predicted to be involved in establishment of epithelial cell polarity. Is an ortholog of human FRMD4A (FERM domain containing 4A) and FRMD4B (FERM domain containing 4B).

madd-2

Caenorhabditis elegans

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).

denn-4

Caenorhabditis elegans

Predicted to be involved in regulation of Rab protein signal transduction. Predicted to be located in cytoplasmic vesicle. Is an ortholog of human DENND4B (DENN domain containing 4B) and DENND4C (DENN domain containing 4C).

ZC190.4

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in P-body. Is an ortholog of human SAMD4B (sterile alpha motif domain containing 4B).

rnp-1

Caenorhabditis elegans

Predicted to enable RNA binding activity. Involved in oocyte fate commitment; positive regulation of oocyte development; and spermatogenesis. Predicted to be located in nuclear speck. Is an ortholog of human RBM4 (RNA binding motif protein 4) and RBM4B (RNA binding motif protein 4B).

aex-3

Caenorhabditis elegans

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in several processes, including egg-laying behavior; mating; and positive regulation of digestive system process. Predicted to be located in cytosol. Expressed in neurons. Used to study alcohol use disorder. Is an ortholog of human MADD (MAP kinase activating death domain).

frm-2

Caenorhabditis elegans

Predicted to enable cytoskeletal protein binding activity. Predicted to be involved in actomyosin structure organization. Predicted to be located in cytoskeleton. Expressed in intestinal cell; pharyngeal epithelial cell; and sensory neurons. Is an ortholog of human EPB41L4B (erythrocyte membrane protein band 4.1 like 4B) and EPB41L5 (erythrocyte membrane protein band 4.1 like 5).

tbb-4

Caenorhabditis elegans

Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in axonemal microtubule. Expressed in HSN; accessory cell; epithelial cell; muscle cell; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Leber congenital amaurosis with early-onset deafness; complex cortical dysplasia with other brain malformations (multiple); and congenital symmetric circumferential skin creases 1. Is an ortholog of human TUBB4B (tubulin beta 4B class IVb).