madd-4

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in dorsal/ventral axon guidance and synapse organization. Located in extracellular space. Expressed in blast cell; coelomocyte; neurons; and somatic nervous system. Is an ortholog of human ADAMTS12 (ADAM metallopeptidase with thrombospondin type 1 motif 12); ADAMTSL1 (ADAMTS like 1); and ADAMTSL3 (ADAMTS like 3).

F13B12.6

Caenorhabditis elegans

Predicted to be located in cytoplasm. Is an ortholog of human SH2D4A (SH2 domain containing 4A).

F07C6.4

Caenorhabditis elegans

Predicted to be involved in establishment of epithelial cell polarity. Is an ortholog of human FRMD4A (FERM domain containing 4A) and FRMD4B (FERM domain containing 4B).

madd-2

Caenorhabditis elegans

Enables protein homodimerization activity; signaling receptor binding activity; and ubiquitin-protein transferase activity. Involved in cell projection organization; protein ubiquitination; and regulation of protein localization. Located in several cellular components, including cell leading edge; neuronal cell body; and striated muscle dense body. Expressed in several structures, including anchor cell; intestinal cell; muscle cell; neurons; and ray precursor cell. Used to study Opitz GBBB syndrome. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome; anencephaly; and non-syndromic X-linked intellectual disability 101. Is an ortholog of human TRIM67 (tripartite motif containing 67) and TRIM9 (tripartite motif containing 9).

cest-2.2

Caenorhabditis elegans

Predicted to be located in membrane. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A).

cest-26

Caenorhabditis elegans

Predicted to enable carboxylic ester hydrolase activity. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A).

cest-32

Caenorhabditis elegans

Predicted to enable carboxylic ester hydrolase activity. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A).

cest-30

Caenorhabditis elegans

Predicted to enable carboxylic ester hydrolase activity. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A).

cest-2.1

Caenorhabditis elegans

Predicted to be located in membrane. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A).

cest-2.3

Caenorhabditis elegans

Predicted to be located in membrane. Human ortholog(s) of this gene implicated in colorectal cancer; hepatocellular carcinoma; and stomach cancer. Is an ortholog of human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A).