Enables protein kinase binding activity. Involved in embryo development; mitotic spindle assembly; and regulation of mitotic sister chromatid separation. Located in kinetochore; nuclear membrane; and nuclear periphery. Expressed in Z1; Z2; Z3; Z4; and intestine. Human ortholog(s) of this gene implicated in lymphoma; mosaic variegated aneuploidy syndrome; and prostate cancer. Is an ortholog of human MAD1L1 (mitotic arrest deficient 1 like 1).
Enables several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and left/right axis specification. Located in adherens junction and nucleus. Part of catenin complex. Expressed in distal tip cell and germ cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; gastrointestinal system cancer (multiple); germ cell cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human JUP (junction plakoglobin).
Enables protein domain specific binding activity and protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan. Located in nucleus. Part of transcription regulator complex. Expressed in tail neurons. Human ortholog(s) of this gene implicated in lung small cell carcinoma and pheochromocytoma. Is an ortholog of human MAX (MYC associated factor X).
Enables protein heterodimerization activity. Contributes to sequence-specific DNA binding activity. Involved in determination of adult lifespan and regulation of cell differentiation. Located in nucleus. Part of transcription regulator complex. Expressed in body wall musculature; neurons; pharynx; and somatic nervous system. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in neurofibrosarcoma and prostate cancer. Is an ortholog of human MXI1 (MAX interactor 1, dimerization protein).