Predicted to enable dynein complex binding activity and microtubule plus-end binding activity. Involved in several processes, including chiasma assembly; microtubule-based process; and organelle localization. Located in cell cortex; perinuclear region of cytoplasm; and supramolecular complex. Part of cytoplasmic dynein complex. Expressed in several structures, including hermaphrodite gonad; hypodermis; neurons; preanal ganglion; and somatic nervous system. Used to study lissencephaly. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lissencephaly 1; and schizophrenia. Is an ortholog of human PAFAH1B1 (platelet activating factor acetylhydrolase 1b regulatory subunit 1).
Predicted to enable microtubule binding activity. Involved in GABAergic synaptic transmission; nuclear migration; and synaptic vesicle transport. Located in nuclear envelope. Expressed in several structures, including hypodermal cell; non-striated muscle; pharyngeal-intestinal valve; rectal valve cell; and tail hypodermis. Used to study epilepsy and lissencephaly. Human ortholog(s) of this gene implicated in lissencephaly 4 and schizophrenia. Is an ortholog of human NDE1 (nudE neurodevelopment protein 1) and NDEL1 (nudE neurodevelopment protein 1 like 1).
Predicted to enable dynein intermediate chain binding activity and microtubule binding activity. Involved in several processes, including establishment of mitotic spindle orientation; regulation of dendrite morphogenesis; and single fertilization. Located in several cellular components, including kinetochore; microtubule cytoskeleton; and midbody. Part of dynactin complex. Expressed in AB; P0; and Psub1. Human ortholog(s) of this gene implicated in Perry syndrome; amyotrophic lateral sclerosis type 1; and autosomal dominant distal hereditary motor neuronopathy 14. Is an ortholog of human DCTN1 (dynactin subunit 1).
Enables dynein light intermediate chain binding activity. Involved in several processes, including centrosome localization; chromosome segregation; and pronuclear migration. Located in centrosome and nuclear envelope. Expressed in gonad and oocyte. Used to study Emery-Dreifuss muscular dystrophy. Is an ortholog of human HOOK1 (hook microtubule tethering protein 1) and HOOK2 (hook microtubule tethering protein 2).