lir-1

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Expressed in several structures, including head; intestinal cell; muscle cell; pharynx; and tail.

lir-3

Caenorhabditis elegans

Predicted to enable DNA binding activity and metal ion binding activity. Predicted to be located in nucleus. Expressed in muscle cell; neurons; spermatheca; and vulva.

lir-2

Caenorhabditis elegans

Enriched in GLR; anchor cell; intestine; neurons; and somatic gonad precursor based on microarray and RNA-seq studies. Is affected by several genes including cyc-1; etr-1; and hsf-1 based on microarray; tiling array; and RNA-seq studies. Is affected by nine chemicals including Tunicamycin; stavudine; and metformin based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domain: Phosphorylation site.

lin-26

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of transcription by RNA polymerase II; tissue development; and vulval development. Located in nucleus. Expressed in several structures, including Z2; epithelial cell; germ line; gonad; and somatic gonad precursor.

atln-1

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in hereditary sensory neuropathy type 1D; hereditary sensory neuropathy type 1F; and hereditary spastic paraplegia 3A. Is an ortholog of human ATL3 (atlastin GTPase 3).

cdh-5

Caenorhabditis elegans

Predicted to enable calcium ion binding activity. Predicted to be involved in cell-cell adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Is an ortholog of human PCDH15 (protocadherin related 15).

exos-9

Caenorhabditis elegans

Predicted to enable mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 1D. Is an ortholog of human EXOSC9 (exosome component 9).

ppm-1.D

Caenorhabditis elegans

Predicted to enable mitogen-activated protein kinase binding activity and protein serine/threonine phosphatase activity. Predicted to be involved in negative regulation of gene expression, epigenetic. Predicted to be located in cytosol and nucleus. Expressed in distal tip cell and germline blastomere. Human ortholog(s) of this gene implicated in breast cancer and pre-malignant neoplasm. Is an ortholog of human PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D).

arf-6

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and positive regulation of endosome to plasma membrane protein transport. Located in basolateral plasma membrane; cytoplasmic side of apical plasma membrane; and recycling endosome membrane. Expressed in several structures, including excretory cell; intestine; pharyngeal muscle cell; ventral nerve cord; and vulva. Is an ortholog of human ARF6 (ADP ribosylation factor 6).

fbl-1

Caenorhabditis elegans

An extracellular matrix structural constituent. Involved in extracellular matrix organization; positive regulation of locomotion; and protein localization. Located in basement membrane. Expressed in ALM; GLR; basal lamina; hyp7 syncytium; and nerve ring. Is an ortholog of human FBLN1 (fibulin 1).