- lip-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable MAP kinase tyrosine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity; and protein tyrosine/threonine phosphatase activity. Involved in several processes, including negative regulation of Ras protein signal transduction; positive regulation of vulval development; and vulval cell fate specification. Located in plasma membrane. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and germ line. Human ortholog(s) of this gene implicated in breast cancer and hypogonadotropic hypogonadism 19 with or without anosmia. Is an ortholog of human DUSP6 (dual specificity phosphatase 6) and DUSP7 (dual specificity phosphatase 7).
- K07E3.4 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable ATP binding activity and formate-tetrahydrofolate ligase activity. Predicted to be involved in tetrahydrofolate interconversion. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal aortic aneurysm; and cleft lip. Is an ortholog of human MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1).
- dep-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatase activity. Involved in positive regulation of vulval development and vulval cell fate specification. Predicted to be located in membrane. Expressed in several structures, including P5.paa; P5.pap; P5.ppa; P5.ppp; and P7.paa. Human ortholog(s) of this gene implicated in several diseases, including breast angiosarcoma; carcinoma (multiple); and central nervous system cancer (multiple). Is an ortholog of human PTPRB (protein tyrosine phosphatase receptor type B).
- T13H5.8 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to be located in endomembrane system and membrane. Human ortholog(s) of this gene implicated in carcinoma (multiple) and pulmonary emphysema. Is an ortholog of human CLPTM1L (CLPTM1 like).