Enables identical protein binding activity. Involved in several processes, including chromosome organization; multicellular organismal locomotion; and muscle cell cellular homeostasis. Predicted to be located in PML body. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite somatic gonadal cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in orofacial cleft 10. Is an ortholog of human SUMO1P1 (SUMO1 pseudogene 1).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including gonad morphogenesis; head morphogenesis; and pharynx development. Located in nucleus. Expressed in several structures, including body wall musculature; head neurons; lumbar neurons; pharyngeal neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including atrial fibrillation; diabetes mellitus (multiple); and heart septal defect (multiple). Is an ortholog of human ISL1 (ISL LIM homeobox 1) and ISL2 (ISL LIM homeobox 2).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including axonal fasciculation; egg-laying behavior; and positive regulation of vulval development. Predicted to be located in nucleus. Expressed in several structures, including head muscle; neurons; somatic nervous system; uterus; and vulva. Is an ortholog of human LHX1 (LIM homeobox 1).
Enables protein domain specific binding activity. Predicted to be involved in positive regulation of stress fiber assembly and regulation of focal adhesion assembly. Located in M band. Expressed in excretory canal; head neurons; non-striated muscle; spermatheca; and vulva. Is an ortholog of human LIMCH1 (LIM and calponin homology domains 1).
Enables protein domain specific binding activity. Located in M band. Expressed in several structures, including body wall musculature; excretory canal; non-striated muscle; spermatheca; and vulva. Is an ortholog of human FHL2 (four and a half LIM domains 2).
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in several processes, including mechanosensory behavior; neuron projection organization; and positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. Expressed in VA neuron; touch receptor neurons; ventral nerve cord; and vulva. Is an ortholog of human LHX1 (LIM homeobox 1) and LHX5 (LIM homeobox 5).
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell differentiation; positive regulation of transcription by RNA polymerase II; and serotonin biosynthetic process. Located in nucleus. Expressed in several structures, including ABalpppppa; head muscle; head neurons; lumbar neurons; and somatic nervous system. Is an ortholog of human LHX6 (LIM homeobox 6) and LHX8 (LIM homeobox 8).
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in neuron development; positive regulation of transcription by RNA polymerase II; and thermosensory behavior. Located in nucleus. Expressed in several structures, including hypodermal cell; neurons; somatic nervous system; spermatheca; and tail. Human ortholog(s) of this gene implicated in panhypopituitarism. Is an ortholog of human LHX3 (LIM homeobox 3).