Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in several processes, including calcium ion import across plasma membrane; cholinergic synaptic transmission; and regulation of multicellular organismal process. Located in neuromuscular junction and postsynaptic membrane. Expressed in ganglia; head muscle; motor neurons; non-striated muscle; and ventral nerve cord. Used to study alcohol use disorder and congenital myasthenic syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autosomal dominant nocturnal frontal lobe epilepsy (multiple); congenital myasthenic syndrome (multiple); and lung disease (multiple). Is an ortholog of human CHRNA2 (cholinergic receptor nicotinic alpha 2 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Enables acetylcholine receptor activity and acetylcholine-gated monoatomic cation-selective channel activity. Involved in regulation of egg-laying behavior; regulation of locomotion; and transmembrane transport. Located in neuron projection; neuronal cell body; and postsynaptic membrane. Expressed in body wall musculature; dorsal nerve cord; nerve ring; ventral cord neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit).
Enables actin filament binding activity. Involved in several processes, including actin filament organization; regulation of actin polymerization or depolymerization; and spicule insertion. Located in striated muscle thin filament. Expressed in several structures, including body wall musculature; germ line; intestine; non-striated muscle; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including congenital myopathy (multiple); distal arthrogryposis type 1A; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including TPM1 (tropomyosin 1); TPM2 (tropomyosin 2); and TPM3 (tropomyosin 3).
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity. Predicted to be involved in excitatory postsynaptic potential and monoatomic ion transmembrane transport. Predicted to be located in neuron projection; plasma membrane; and synapse. Predicted to be part of acetylcholine-gated channel complex. Expressed in several structures, including DD neuron; anal depressor muscle; ganglia; head neurons; and uterine-vulval cell. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 1A and congenital myasthenic syndrome 1B. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit).