vps-34 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including determination of adult lifespan; ecdysis, collagen and cuticulin-based cuticle; and regulation of transport. Located in cytoplasm; nuclear outer membrane; and nucleolus. Is an ortholog of human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3).
mtm-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; phosphatidylinositol-3-phosphate phosphatase activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in negative regulation of engulfment of apoptotic cell and phospholipid dephosphorylation. Located in apical cortex; cytosol; and plasma membrane. Expressed in several structures, including coelomocyte; hermaphrodite somatic gonadal cell; neurons; pharynx; and vulva. Used to study centronuclear myopathy. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4B1 and congenital structural myopathy. Is an ortholog of human MTM1 (myotubularin 1); MTMR1 (myotubularin related protein 1); and MTMR2 (myotubularin related protein 2).