let-23

Caenorhabditis elegans

Enables epidermal growth factor receptor activity; lipid binding activity; and molecular function activator activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including apoptotic cell; egg-laying apparatus; excretory duct cell; head; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Is an ortholog of human EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4).

kin-31

Caenorhabditis elegans

Expressed in body wall musculature.

kin-10

Caenorhabditis elegans

Predicted to enable protein kinase regulator activity. Involved in response to hermaphrodite contact and vulval location. Located in neuronal cell body; nucleus; and plasma membrane bounded cell projection. Part of protein kinase CK2 complex. Expressed in germ cell; gonad; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in leiomyoma. Is an ortholog of human CSNK2B (casein kinase 2 beta).

kin-32

Caenorhabditis elegans

Predicted to enable ATP binding activity and protein tyrosine kinase activity. Predicted to be involved in regulation of cellular component organization and signal complex assembly. Predicted to be located in dendritic spine; focal adhesion; and plasma membrane. Expressed in body wall musculature; head mesodermal cell; head neurons; and uterine muscle. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); ductal carcinoma in situ; and endometrial hyperplasia. Is an ortholog of human PTK2 (protein tyrosine kinase 2).

kin-23

Caenorhabditis elegans

Enriched in CEPsoDL; CEPsoVL; and head mesodermal cell based on RNA-seq and single-cell RNA-seq studies. Is affected by several genes including mter-4; etr-1; and rsr-2 based on tiling array; RNA-seq; and microarray studies. Is affected by six chemicals including Psoralens; allantoin; and Sirolimus based on RNA-seq and microarray studies.

kin-1

Caenorhabditis elegans

Enables cAMP-dependent protein kinase activity. Involved in positive regulation of oocyte maturation. Predicted to be located in cytosol and nucleus. Predicted to be part of cAMP-dependent protein kinase complex. Expressed in several structures, including excretory cell; gonad; head muscle; intestine; and ventral cord neurons. Human ortholog(s) of this gene implicated in several diseases, including adrenal cortical adenoma; fibrolamellar carcinoma; and platelet-type bleeding disorder 19. Is an ortholog of human PRKACA (protein kinase cAMP-activated catalytic subunit alpha).

kin-5

Caenorhabditis elegans

Predicted to enable protein tyrosine kinase activity. Predicted to be located in plasma membrane.

kin-16

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in hyp6 and hyp7 syncytium.

kin-19

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Involved in Wnt signaling pathway, regulating spindle positioning and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytoplasm; and nucleus. Expressed in several structures, including BDU; marginal cell; seam cell; tail; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease and inclusion body myositis. Is an ortholog of human CSNK1A1 (casein kinase 1 alpha 1).

kin-15

Caenorhabditis elegans

Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in hyp6 and hyp7 syncytium.