Predicted to enable aldose reductase (NADPH) activity. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia (multiple); artery disease (multiple); and carcinoma (multiple). Is an ortholog of human AKR1B1 (aldo-keto reductase family 1 member B); AKR1B10 (aldo-keto reductase family 1 member B10); and AKR1B15 (aldo-keto reductase family 1 member B15).
Predicted to enable aldose reductase (NADPH) activity. Predicted to be involved in small molecule metabolic process. Predicted to be located in cytosol. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including diabetic neuropathy; gastrointestinal system cancer (multiple); and type 2 diabetes mellitus. Is an ortholog of human AKR1B1 (aldo-keto reductase family 1 member B); AKR1B10 (aldo-keto reductase family 1 member B10); and AKR1B15 (aldo-keto reductase family 1 member B15).
Predicted to enable 3-dehydrosphinganine reductase activity. Predicted to be involved in 3-keto-sphinganine metabolic process and sphingolipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 4 and follicular lymphoma. Is an ortholog of human KDSR (3-ketodihydrosphingosine reductase).
Predicted to enable 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity and metal ion binding activity. Predicted to be involved in branched-chain amino acid catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Is an ortholog of human BCKDHA (branched chain keto acid dehydrogenase E1 subunit alpha).
Predicted to enable aldose reductase (NADPH) activity. Predicted to be involved in small molecule metabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia (multiple); castration-resistant prostate carcinoma; and ductal carcinoma in situ. Is an ortholog of human AKR1B15 (aldo-keto reductase family 1 member B15).
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Expressed in pharyngeal muscle cell and rectal epithelium. Is an ortholog of human INPP5A (inositol polyphosphate-5-phosphatase A).
Predicted to enable catalytic activity. Involved in positive regulation of fatty acid biosynthetic process and positive regulation of nematode larval development. Predicted to be located in mitochondrion. Predicted to be part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in maple syrup urine disease. Is an ortholog of human BCKDHB (branched chain keto acid dehydrogenase E1 subunit beta).