Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane and protein-containing complex. Expressed in gonad. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Is an ortholog of human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2).
Enables calcium ion binding activity. Involved in several processes, including determination of adult lifespan; hemidesmosome assembly; and response to stress. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; neurons; and pharynx. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin).
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; mating behavior; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; autosomal dominant cerebellar ataxia (multiple); and diabetes mellitus (multiple). Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in defecation and rhythmic behavior. Predicted to be located in dendritic spine; postsynaptic density; and postsynaptic membrane. Expressed in several structures, including egg-laying apparatus; neurons; pharyngeal-intestinal valve; somatic nervous system; and tail ganglion. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome; autistic disorder; and schizophrenia 15. Is an ortholog of human SHANK1 (SH3 and multiple ankyrin repeat domains 1).
Enables actin filament binding activity and microfilament motor activity. A structural constituent of muscle. Involved in several processes, including egg-laying behavior; muscle contraction; and skeletal muscle myosin thick filament assembly. Located in A band and striated muscle myosin thick filament. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; head; vulval muscle; and in male. Human ortholog(s) of this gene implicated in several diseases, including congenital heart disease (multiple); distal myopathy 1; and intrinsic cardiomyopathy (multiple). Is an ortholog of several human genes including MYH1 (myosin heavy chain 1); MYH2 (myosin heavy chain 2); and MYH3 (myosin heavy chain 3).
Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and calmodulin binding activity. Involved in protein localization and regulation of mitotic spindle elongation. Located in plasma membrane. Expressed in egg-laying apparatus; gonad; seam cell; and ventral nerve cord. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Is an ortholog of human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha).