Enables UDP-N-acetylglucosamine 4-epimerase activity and UDP-glucose 4-epimerase activity. Involved in several processes, including gonad morphogenesis; negative regulation of endoplasmic reticulum unfolded protein response; and positive regulation of vulval development. Predicted to be located in cytosol. Expressed in head. Used to study galactosemia. Human ortholog(s) of this gene implicated in galactose epimerase deficiency. Is an ortholog of human GALE (UDP-galactose-4-epimerase).
Predicted to enable cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Located in endoplasmic reticulum membrane and protein-containing complex. Expressed in gonad. Used to study hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18 and hereditary spastic paraplegia 62. Is an ortholog of human ERLIN1 (ER lipid raft associated 1) and ERLIN2 (ER lipid raft associated 2).
Predicted to enable chitin synthase activity. Involved in chitin biosynthetic process; eggshell formation; and positive regulation of protein localization to cell cortex. Located in cell cortex and plasma membrane. Expressed in Psub1.
Enables calcium ion binding activity. Involved in several processes, including determination of adult lifespan; hemidesmosome assembly; and response to stress. Located in cytoplasm. Expressed in several structures, including coelomocyte; excretory system; intestine; neurons; and pharynx. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Is an ortholog of human CALR (calreticulin).
Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; mating behavior; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; autosomal dominant cerebellar ataxia (multiple); and diabetes mellitus (multiple). Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).
Predicted to enable ionotropic glutamate receptor binding activity and synaptic receptor adaptor activity. Involved in defecation and rhythmic behavior. Predicted to be located in dendritic spine; postsynaptic density; and postsynaptic membrane. Expressed in several structures, including egg-laying apparatus; neurons; pharyngeal-intestinal valve; somatic nervous system; and tail ganglion. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome; autistic disorder; and schizophrenia 15. Is an ortholog of human SHANK1 (SH3 and multiple ankyrin repeat domains 1).
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in spermatid development. Located in extracellular space and secretory vesicle. Expressed in body wall musculature; coelomocyte; reproductive tract; and in male.
Enables aryl sulfotransferase activity. Involved in sulfur compound metabolic process. Located in cytosol. Expressed in ASJL and ASJR. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung non-small cell carcinoma (multiple); and reproductive organ cancer (multiple). Is an ortholog of several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1E1 (sulfotransferase family 1E member 1).