ina-1

Caenorhabditis elegans

Enables transmembrane signaling receptor activity. Involved in several processes, including anatomical structure morphogenesis; cell-cell adhesion mediated by integrin; and generation of neurons. Located in phagocytic cup. Part of integrin complex. Expressed in several structures, including distal tip cell; hermaphrodite gonad; neurons; ventral nerve cord; and vulE. Used to study cancer and epilepsy. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and junctional epidermolysis bullosa with pyloric atresia. Is an ortholog of human ITGA6 (integrin subunit alpha 6).

src-1

Caenorhabditis elegans

Enables netrin receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including anatomical structure morphogenesis; axis specification; and establishment of mitotic spindle orientation. Located in contractile muscle fiber and phagocytic cup. Expressed in several structures, including anchor cell; anus; distal tip cell; head neurons; and vulval cell. Used to study Goldenhar syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; diabetes mellitus (multiple); gastrointestinal system cancer (multiple); and lung non-small cell carcinoma (multiple). Is an ortholog of human FYN (FYN proto-oncogene, Src family tyrosine kinase); SRC (SRC proto-oncogene, non-receptor tyrosine kinase); and YES1 (YES proto-oncogene 1, Src family tyrosine kinase).

unc-71

Caenorhabditis elegans

Predicted to enable metalloendopeptidase activity. Predicted to be involved in membrane protein ectodomain proteolysis. Located in membrane. Expressed in several structures, including buccal cavity; excretory system; nerve ring; neuronal sheath cell; and neurons. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 61. Is an ortholog of human ADAM22 (ADAM metallopeptidase domain 22) and ADAM23 (ADAM metallopeptidase domain 23).

mig-15

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including dorsal/ventral axon guidance; nematode larval development; and regulation of GABAergic synaptic transmission. Predicted to be located in cytoplasm. Expressed in several structures, including QL; QR; body wall musculature; pharynx; and somatic nervous system. Used to study epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive intellectual developmental disorder 54; gastrointestinal system cancer (multiple); and hepatitis B. Is an ortholog of human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4); MINK1 (misshapen like kinase 1); and TNIK (TRAF2 and NCK interacting kinase).