che-11

Caenorhabditis elegans

Involved in several processes, including dauer entry; positive regulation of intracellular transport; and response to stress. Located in non-motile cilium. Expressed in head and neurons. Human ortholog(s) of this gene implicated in retinitis pigmentosa and short-rib thoracic dysplasia 9 with or without polydactyly. Is an ortholog of human IFT140 (intraflagellar transport 140).

let-140

Caenorhabditis elegans

ift-74

Caenorhabditis elegans

Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 22; Joubert syndrome; and spermatogenic failure 58. Is an ortholog of human IFT74 (intraflagellar transport 74).

ift-81

Caenorhabditis elegans

Enables microtubule binding activity. Involved in chemotaxis; detection of stimulus involved in sensory perception; and intraciliary transport. Located in non-motile cilium. Expressed in amphid neurons; chemosensory neurons; and phasmid neurons. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Is an ortholog of human IFT81 (intraflagellar transport 81).

arl-13

Caenorhabditis elegans

Predicted to enable GTP binding activity and GTPase activity. Involved in cilium organization; receptor localization to non-motile cilium; and sensory perception of chemical stimulus. Acts upstream of or within motile cilium assembly. Located in plasma membrane bounded cell projection. Expressed in ciliated neurons and head. Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome 8. Is an ortholog of human ARL13B (ADP ribosylation factor like GTPase 13B).

dyf-19

Caenorhabditis elegans

Involved in non-motile cilium assembly. Located in ciliary basal body and dendrite. Expressed in ciliated neurons. Is an ortholog of human FBF1 (Fas binding factor 1).

ift-20

Caenorhabditis elegans

Predicted to be involved in centrosome localization; intraciliary transport; and protein localization to cilium. Located in dendrite; neuronal cell body; and non-motile cilium. Expressed in ciliated neurons; sensory neurons; and tail. Is an ortholog of human IFT20 (intraflagellar transport 20).

dyf-13

Caenorhabditis elegans

Predicted to enable intraciliary transport particle B binding activity. Predicted to be involved in intraciliary anterograde transport and intraciliary transport involved in cilium assembly. Predicted to be located in ciliary basal body and ciliary base. Predicted to be part of intraciliary transport particle B. Expressed in neurons. Is an ortholog of human IFT56 (intraflagellar transport 56).

ifta-2

Caenorhabditis elegans

Predicted to enable GTPase activity. Involved in several processes, including dauer larval development; determination of adult lifespan; and insulin-like growth factor receptor signaling pathway. Located in axoneme and ciliary base. Expressed in amphid neurons and phasmid neurons. Is an ortholog of human IFT22 (intraflagellar transport 22).

che-10

Caenorhabditis elegans

Involved in cilium assembly. Located in ciliary basal body and ciliary transition zone. Is an ortholog of human CEP250 (centrosomal protein 250) and CROCC (ciliary rootlet coiled-coil, rootletin).