Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi lumen. Expressed in several structures, including coelomocyte; distal tip cell; neurons; non-striated muscle; and rectal epithelial cell. Is an ortholog of human HS3ST1 (heparan sulfate-glucosamine 3-sulfotransferase 1) and HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5).
Enables heparan sulfate 2-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification; regulation of growth; and regulation of locomotion. Predicted to be located in Golgi apparatus. Expressed in several structures, including P6.paa; P6.pap; P6.ppa; hermaphrodite distal tip cell; and somatic nervous system. Is an ortholog of human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1).
Predicted to enable heparan sulfate 6-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process, enzymatic modification and regulation of growth. Predicted to be located in membrane. Expressed in AIBL; AIBR; RIML; RIMR; and neurons. Human ortholog(s) of this gene implicated in Paganini-Miozzo syndrome and hypogonadotropic hypogonadism 15 with or without anosmia. Is an ortholog of human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1).
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Is an ortholog of several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3).
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in L-leucine catabolic process and ketone body biosynthetic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is an ortholog of human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase) and HMGCLL1 (3-hydroxy-3-methylglutaryl-CoA lyase like 1).