hsp-90

Caenorhabditis elegans

Enables several functions, including ATP hydrolysis activity; nuclear glucocorticoid receptor binding activity; and protein phosphatase 5 binding activity. Involved in several processes, including determination of adult lifespan; protein export from nucleus; and response to stress. Located in perinuclear region of cytoplasm and protein-containing complex. Expressed in several structures, including excretory system; germ line; intestine; nerve ring; and pharynx. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; autoimmune disease (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human HSP90AB1 (heat shock protein 90 alpha family class B member 1).

utp-20

Caenorhabditis elegans

Predicted to be located in nucleolus. Predicted to be part of 90S preribosome and small-subunit processome. Is an ortholog of human UTP20 (UTP20 small subunit processome component).

F18C12.3

Caenorhabditis elegans

Predicted to be involved in maturation of SSU-rRNA. Predicted to be located in nucleus. Predicted to be part of 90S preribosome. Is an ortholog of human SRFBP1 (serum response factor binding protein 1).

hsp-16.11

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response.

ZK792.5

Caenorhabditis elegans

Predicted to enable RNA binding activity. Predicted to be involved in ribosome biogenesis. Predicted to be located in nucleolus. Predicted to be part of 90S preribosome and preribosome, small subunit precursor. Is an ortholog of human NOP9 (NOP9 nucleolar protein).

B0280.9

Caenorhabditis elegans

Predicted to be involved in rRNA processing. Predicted to be located in nucleolus. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is an ortholog of human UTP18 (UTP18 small subunit processome component).

T22H9.1

Caenorhabditis elegans

Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleolus. Predicted to be part of 90S preribosome. Is an ortholog of human RRP36 (ribosomal RNA processing 36).

hsp-16.49

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A).

hsp-16.2

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in response to heat. Located in cytoplasm. Expressed in several structures, including coelomocyte; enteric muscle; gonad; somatic nervous system; and spermatid.

hsp-12.6

Caenorhabditis elegans

Enables identical protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; and spermatid. Human ortholog(s) of this gene implicated in cataract (multiple); dilated cardiomyopathy 1II; and myofibrillar myopathy (multiple). Is an ortholog of human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6).