hsp-2

Caenorhabditis elegans

Enriched in germ line based on proteomic studies. Is affected by several genes including mut-16; hrde-1; and emb-4 based on proteomic; microarray; and RNA-seq studies. Is affected by seven chemicals including metformin; allantoin; and Sirolimus based on RNA-seq studies.

hsp-16.11

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response.

hsp-16.49

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in endoplasmic reticulum unfolded protein response. Human ortholog(s) of this gene implicated in cataract 9 multiple types. Is an ortholog of human CRYAA (crystallin alpha A).

hsp-16.2

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in response to heat. Located in cytoplasm. Expressed in several structures, including coelomocyte; enteric muscle; gonad; somatic nervous system; and spermatid.

hsp-12.6

Caenorhabditis elegans

Enables identical protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; and spermatid. Human ortholog(s) of this gene implicated in cataract (multiple); dilated cardiomyopathy 1II; and myofibrillar myopathy (multiple). Is an ortholog of human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6).

hsp-6

Caenorhabditis elegans

Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in mitochondrial unfolded protein response. Located in mitochondrion. Expressed in muscle cell. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; autosomal dominant sideroblastic anemia 4; and rheumatoid arthritis. Is an ortholog of human HSPA9 (heat shock protein family A (Hsp70) member 9).

21ur-2624

Caenorhabditis elegans

Is affected by several genes including numr-2; numr-1; and hsp-6 based on RNA-seq studies.

Y24D9A.14

Caenorhabditis elegans

Is affected by several genes including etr-1; hsp-6; and mrps-5 based on RNA-seq studies.

hsp-16.1

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Involved in defense response to Gram-negative bacterium and response to heat. Located in Golgi medial cisterna. Expressed in several structures, including coelomocyte; enteric muscle; intestine; pharynx; and ventral nerve cord.

Y51A2A.2

Caenorhabditis elegans

Is affected by several genes including hsp-6; mrps-5; and dpy-21 based on microarray and RNA-seq studies.