sop-3

Caenorhabditis elegans

Predicted to be located in nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.

ceh-13

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity. Involved in cell-cell adhesion and embryo development. Located in cytoplasm and nucleus. Expressed in several structures, including embryonic cell; hypodermis; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in Athabaskan brainstem dysgenesis syndrome and autistic disorder. Is an ortholog of human HOXB1 (homeobox B1) and HOXD1 (homeobox D1).

ham-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in cell fate determination; cell migration; and regulation of neuron differentiation. Located in nucleus.

nob-1

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in several processes, including nematode male tail tip morphogenesis; pattern specification process; and positive regulation of miRNA transcription. Located in nucleus. Expressed in head muscle; intestine; linker cell; somatic nervous system; and tail. Is an ortholog of several human genes including HOXA9 (homeobox A9); HOXB9 (homeobox B9); and HOXC10 (homeobox C10).

aos-1

Caenorhabditis elegans

Contributes to SUMO activating enzyme activity. Involved in protein sumoylation. Predicted to be located in cytoplasm. Predicted to be part of SUMO activating enzyme complex. Is an ortholog of human SAE1 (SUMO1 activating enzyme subunit 1).

eor-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; nematode male tail tip morphogenesis; and signal transduction. Located in nucleus. Expressed in several structures, including dorsal nerve cord; gonad; pharynx; and vulval precursor cell.

lin-25

Caenorhabditis elegans

Involved in defense response to Gram-positive bacterium and vulval development. Acts upstream of or within with a positive effect on cell fate specification. Located in cytoplasm and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; hermaphrodite distal tip cell; and vulval cell.

uba-2

Caenorhabditis elegans

Enables SUMO activating enzyme activity. Involved in several processes, including anterior/posterior pattern specification; nematode larval development; and protein sumoylation. Predicted to be located in cytoplasm. Predicted to be part of SUMO activating enzyme complex. Is an ortholog of human UBA2 (ubiquitin like modifier activating enzyme 2).

mig-13

Caenorhabditis elegans

Involved in positive regulation of cell migration. Located in axon; neuronal cell body; and plasma membrane. Expressed in several structures, including QR.a; QR.p; QR.pa; body ganglion; and somatic neurons.

sor-3

Caenorhabditis elegans

Predicted to enable chromatin binding activity and histone binding activity. Involved in several processes, including negative regulation of DNA-templated transcription; nematode larval development; and neuron differentiation. Located in cytoplasm and nucleus. Expressed widely.