hop-1

Caenorhabditis elegans

Predicted to enable endopeptidase activity. Involved in Notch signaling pathway and positive regulation of germ cell proliferation. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of gamma-secretase complex.

spr-2

Caenorhabditis elegans

Predicted to enable chromatin binding activity and histone binding activity. Involved in regulation of egg-laying behavior. Located in nucleus. Expressed widely. Human ortholog(s) of this gene implicated in several diseases, including hepatocellular carcinoma; seminoma; and sudden infant death syndrome. Is an ortholog of human SET (SET nuclear proto-oncogene) and SETSIP (SET like protein).

ceh-89

Caenorhabditis elegans

Predicted to enable DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in neurons. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Is an ortholog of human HOPX (HOP homeobox).

sel-12

Caenorhabditis elegans

Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2).

sti-1

Caenorhabditis elegans

Enables ATPase inhibitor activity; Hsp70 protein binding activity; and Hsp90 protein binding activity. Involved in determination of adult lifespan and response to heat. Located in cytoplasm. Expressed in several structures, including gonad; male-specific anatomical entity; pharyngeal muscle cell; touch receptor neurons; and vulva. Is an ortholog of human STIP1 (stress induced phosphoprotein 1).

spr-5

Caenorhabditis elegans

Enables FAD-dependent H3K4me/H3K4me3 demethylase activity. Involved in epigenetic regulation of gene expression. Located in cytoplasm and nucleus. Expressed in germ line. Human ortholog(s) of this gene implicated in several diseases, including alopecia areata; diabetic retinopathy; and hepatocellular carcinoma. Is an ortholog of human KDM1A (lysine demethylase 1A).