Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in several processes, including generation of neurons; positive regulation of transcription by RNA polymerase II; and protein localization. Located in cell cortex and nucleus. Expressed in neuroblasts. Human ortholog(s) of this gene implicated in Alzheimer's disease and pre-eclampsia. Is an ortholog of human STOX1 (storkhead box 1).
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in cell fate determination; cell migration; and regulation of neuron differentiation. Located in nucleus.
Enriched in M.vrpaapap; anal depressor muscle; and mu_int_L based on single-cell RNA-seq studies. Is affected by ham-3 and daf-2 based on RNA-seq and microarray studies. Is affected by Colistin based on microarray studies.
Enables DNA-binding transcription factor binding activity; transcription coactivator activity; and transcription corepressor activity. Involved in determination of adult lifespan; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including HSNL and HSNR. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 11. Is an ortholog of human SMARCD1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1); SMARCD2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2); and SMARCD3 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3).