Enables protein serine/threonine kinase activity. Involved in several processes, including engulfment of apoptotic cell; left/right axis specification; and regulation of cellular component organization. Predicted to be located in cytosol and nucleus. Expressed in distal tip cell; seam cell; and sperm. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; bipolar disorder; carcinoma (multiple); and degenerative disc disease. Is an ortholog of human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta).
Enables hexosaminidase activity and protein serine/threonine phosphatase activity. Involved in several processes, including dauer larval development; glycogen metabolic process; and negative regulation of protein glycosylation. Expressed in body wall musculature; coelomocyte; nerve ring; pharyngeal muscle cell; and rectal muscle. Used to study type 2 diabetes mellitus. Is an ortholog of human OGA (O-GlcNAcase).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including intracellular membrane-bounded organelle; neuronal cell body; and striated muscle dense body. Expressed in ASIL; ASIR; head; muscle cell; and tail. Is an ortholog of human DCAF11 (DDB1 and CUL4 associated factor 11).
Enables beta-catenin binding activity. Involved in several processes, including embryonic morphogenesis; regulation of Wnt signaling pathway; and regulation of multicellular organismal development. Located in adherens junction; cell cortex; and nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; distal tip cell; and excretory cell. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Sotos syndrome 3; carcinoma (multiple); and gastrointestinal system cancer (multiple). Is an ortholog of human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2).