sgs-2

Caenorhabditis elegans

asp-3

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Expressed in intestine and uterus. Is an ortholog of human NAPSA (napsin A aspartic peptidase).

acy-2

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity. Involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway and nematode larval development. Predicted to be located in plasma membrane. Expressed in CANL; CANR; head ganglion; and ventral cord neurons. Is an ortholog of human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7).

asp-4

Caenorhabditis elegans

Predicted to enable aspartic-type endopeptidase activity. Involved in programmed necrotic cell death. Located in lysosome. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; and neuronal ceroid lipofuscinosis 10. Is an ortholog of human CTSD (cathepsin D).

acy-1

Caenorhabditis elegans

Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9).

clp-6

Caenorhabditis elegans

Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be located in cytoplasm. Expressed in hypodermis. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of several human genes including CAPN1 (calpain 1); CAPN2 (calpain 2); and CAPN3 (calpain 3).

aex-2

Caenorhabditis elegans

Predicted to enable neuropeptide receptor activity. Involved in several processes, including lipid transport involved in lipid storage; positive regulation of digestive system process; and positive regulation of triglyceride transport. Predicted to be located in cilium and plasma membrane. Expressed in alimentary muscle; head mesodermal cell; intestine; and nervous system.

gsa-1

Caenorhabditis elegans

Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Involved in several processes, including negative regulation of protein kinase C signaling; nematode pharyngeal pumping; and positive regulation of oocyte maturation. Predicted to be located in cytoplasm. Predicted to be part of heterotrimeric G-protein complex. Expressed in several structures, including excretory cell; intestine; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; Alzheimer's disease; dystonia 25; and pseudohypoparathyroidism (multiple). Is an ortholog of human GNAL (G protein subunit alpha L).

clp-1

Caenorhabditis elegans

Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Involved in several processes, including cellular response to calcium ion; muscle cell cellular homeostasis; and positive regulation of sarcomere organization. Located in M band. Expressed in GABAergic neurons; hypodermis; intestine; pharyngeal muscle cell; and vulva. Used to study Duchenne muscular dystrophy and hereditary spastic paraplegia. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; and stomach cancer. Is an ortholog of human CAPN3 (calpain 3) and CAPN9 (calpain 9).

ric-8

Caenorhabditis elegans

Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including negative regulation of protein kinase C signaling; protein localization to cell cortex; and regulation of feeding behavior. Located in aster; cell cortex; and kinetochore microtubule. Expressed in germ line and neurons. Is an ortholog of human RIC8A (RIC8 guanine nucleotide exchange factor A).