grk-2

Caenorhabditis elegans

Predicted to enable G protein-coupled receptor binding activity and G protein-coupled receptor kinase activity. Involved in several processes, including positive regulation of egg-laying behavior; positive regulation of growth rate; and serotonin catabolic process. Expressed in neurons and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including opiate dependence; rheumatoid arthritis; and toxic shock syndrome. Is an ortholog of human GRK2 (G protein-coupled receptor kinase 2) and GRK3 (G protein-coupled receptor kinase 3).

grk-1

Caenorhabditis elegans

Predicted to enable protein kinase activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Oguchi disease-2; essential hypertension; and rheumatoid arthritis. Is an ortholog of human GRK5 (G protein-coupled receptor kinase 5) and GRK6 (G protein-coupled receptor kinase 6).

zim-2

Caenorhabditis elegans

Predicted to be involved in meiotic chromosome segregation. Located in condensed nuclear chromosome.

dop-3

Caenorhabditis elegans

Enables dopamine neurotransmitter receptor activity, coupled via Gi/Go. Involved in several processes, including adenylate cyclase-inhibiting dopamine receptor signaling pathway; male mating behavior; and response to odorant. Predicted to be located in plasma membrane. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; alcohol dependence; drug dependence (multiple); and end stage renal disease. Is an ortholog of human DRD3 (dopamine receptor D3).

arr-1

Caenorhabditis elegans

Predicted to enable G protein-coupled receptor binding activity. Involved in positive regulation of growth rate. Predicted to be located in cytoplasm. Expressed in HSN; amphid neurons; somatic nervous system; and tail. Human ortholog(s) of this gene implicated in several diseases, including eye disease (multiple); heroin dependence; and liver disease (multiple). Is an ortholog of human ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2).

mau-2

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity. Involved in anterior/posterior axon guidance; dorsal/ventral axon guidance; and egg-laying behavior. Located in axon and cytoplasm. Expressed in nervous system; oocyte; and vulval muscle. Is an ortholog of human MAU2 (MAU2 sister chromatid cohesion factor).