malt-1

Caenorhabditis elegans

Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Expressed in RMG and oxygen sensory neurons. Human ortholog(s) of this gene implicated in immunodeficiency 12 and non-Hodgkin lymphoma. Is an ortholog of human MALT1 (MALT1 paracaspase).

frg-1

Caenorhabditis elegans

Enables actin filament binding activity and protein homodimerization activity. Involved in actin filament bundle assembly. Located in nucleolus and striated muscle dense body. Used to study facioscapulohumeral muscular dystrophy. Is an ortholog of human FRG1 (FSHD region gene 1).

D2045.9

Caenorhabditis elegans

Predicted to enable procollagen galactosyltransferase activity. Human ortholog(s) of this gene implicated in brain small vessel disease 3. Is an ortholog of human COLGALT1 (collagen beta(1-O)galactosyltransferase 1) and COLGALT2 (collagen beta(1-O)galactosyltransferase 2).

acl-2

Caenorhabditis elegans

Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in phosphatidic acid biosynthetic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital generalized lipodystrophy type 1. Is an ortholog of human AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1) and AGPAT2 (1-acylglycerol-3-phosphate O-acyltransferase 2).

bgal-1

Caenorhabditis elegans

Predicted to enable beta-galactosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be located in vacuole. Human ortholog(s) of this gene implicated in GM1 gangliosidosis (multiple) and mucopolysaccharidosis type IVB. Is an ortholog of human GLB1L (galactosidase beta 1 like).

K04F10.1

Caenorhabditis elegans

Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1. Is an ortholog of human ATXN1L (ataxin 1 like).

lpl-1

Caenorhabditis elegans

Predicted to enable lipoyl(octanoyl) transferase activity. Predicted to be involved in protein modification process. Predicted to be located in mitochondrion. Is an ortholog of human LIPT2 (lipoyl(octanoyl) transferase 2).

mccc-1

Caenorhabditis elegans

Predicted to enable ATP binding activity and ligase activity. Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in 3-methylcrotonyl-CoA carboxylase 1 deficiency. Is an ortholog of human MCCC1 (methylcrotonyl-CoA carboxylase subunit 1).

htz-1

Caenorhabditis elegans

Predicted to enable nucleosomal DNA binding activity. Involved in negative regulation of DNA-templated transcription and negative regulation of cell fate specification. Located in condensed chromosome and nucleus. Part of chromatin. Expressed in several structures, including distal tip cell and somatic gonad. Is an ortholog of human H2AZ2 (H2A.Z variant histone 2).

znf-706

Caenorhabditis elegans

Predicted to be located in cytoplasm and nucleus. Is an ortholog of human ZNF706 (zinc finger protein 706).