gem-4

Caenorhabditis elegans

Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be located in plasma membrane. Expressed in several structures, including Z2; Z3; head mesodermal cell; hermaphrodite gonad; and somatic gonad precursor. Is an ortholog of human CPNE5 (copine 5) and CPNE9 (copine family member 9).

F10E9.5

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of SMN complex. Is an ortholog of human GEMIN8 (gem nuclear organelle associated protein 8).

Y52B11A.4

Caenorhabditis elegans

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in congestive heart failure and type 2 diabetes mellitus. Is an ortholog of human REM1 (RRAD and GEM like GTPase 1); REM2 (RRAD and GEM like GTPase 2); and RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator).

D1007.4

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Located in striated muscle dense body. Is an ortholog of human GEMIN6 (gem nuclear organelle associated protein 6).

C24H11.5

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of Sm-like protein family complex. Is an ortholog of human GEMIN7 (gem nuclear organelle associated protein 7).

cox-6B

Caenorhabditis elegans

Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 7. Is an ortholog of human COX6B1 (cytochrome c oxidase subunit 6B1).

spv-1

Caenorhabditis elegans

Enables GTPase activator activity. Involved in several processes, including cell-cell junction assembly; negative regulation of smooth muscle contraction; and regulation of protein localization. Located in apical plasma membrane and cell-cell junction. Expressed in head neurons; hypodermis; spermatheca; spermathecal cell; and tail neurons. Is an ortholog of human GMIP (GEM interacting protein).

cox-4

Caenorhabditis elegans

Involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 16. Is an ortholog of human COX4I1 (cytochrome c oxidase subunit 4I1) and COX4I2 (cytochrome c oxidase subunit 4I2).

let-656

Caenorhabditis elegans

lig-4

Caenorhabditis elegans

Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Expressed in head neurons; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; multiple myeloma; and prostate cancer. Is an ortholog of human LIG4 (DNA ligase 4).