gem-4

Caenorhabditis elegans

Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be located in plasma membrane. Expressed in several structures, including Z2; Z3; head mesodermal cell; hermaphrodite gonad; and somatic gonad precursor. Is an ortholog of human CPNE5 (copine 5) and CPNE9 (copine family member 9).

F10E9.5

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of SMN complex. Is an ortholog of human GEMIN8 (gem nuclear organelle associated protein 8).

Y52B11A.4

Caenorhabditis elegans

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in congestive heart failure and type 2 diabetes mellitus. Is an ortholog of human REM1 (RRAD and GEM like GTPase 1); REM2 (RRAD and GEM like GTPase 2); and RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator).

D1007.4

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Located in striated muscle dense body. Is an ortholog of human GEMIN6 (gem nuclear organelle associated protein 6).

C24H11.5

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of Sm-like protein family complex. Is an ortholog of human GEMIN7 (gem nuclear organelle associated protein 7).

vps-15

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in autophagy and vacuolar transport. Predicted to be located in late endosome and nucleus-vacuole junction. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Is an ortholog of human PIK3R4 (phosphoinositide-3-kinase regulatory subunit 4).

rpac-40

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Is an ortholog of human POLR1C (RNA polymerase I and III subunit C).

rpc-11

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity; nucleic acid binding activity; and zinc ion binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in termination of RNA polymerase III transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 21. Is an ortholog of human POLR3K (RNA polymerase III subunit K).

rpc-2

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleus. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease and hypomyelinating leukodystrophy 8. Is an ortholog of human POLR3B (RNA polymerase III subunit B).

rpc-1

Caenorhabditis elegans

Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nuclear lumen and protein-containing complex. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Is an ortholog of human POLR3A (RNA polymerase III subunit A).