Y52B11A.4

Caenorhabditis elegans

Predicted to enable GTP binding activity and calcium channel regulator activity. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in congestive heart failure and type 2 diabetes mellitus. Is an ortholog of human REM1 (RRAD and GEM like GTPase 1); REM2 (RRAD and GEM like GTPase 2); and RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator).

gem-4

Caenorhabditis elegans

Predicted to enable calcium-dependent phospholipid binding activity. Predicted to be involved in cellular response to calcium ion. Predicted to be located in plasma membrane. Expressed in several structures, including Z2; Z3; head mesodermal cell; hermaphrodite gonad; and somatic gonad precursor. Is an ortholog of human CPNE5 (copine 5) and CPNE9 (copine family member 9).

F10E9.5

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of SMN complex. Is an ortholog of human GEMIN8 (gem nuclear organelle associated protein 8).

D1007.4

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Located in striated muscle dense body. Is an ortholog of human GEMIN6 (gem nuclear organelle associated protein 6).

C24H11.5

Caenorhabditis elegans

Predicted to be involved in spliceosomal snRNP assembly. Predicted to be part of Sm-like protein family complex. Is an ortholog of human GEMIN7 (gem nuclear organelle associated protein 7).

rpap-2

Caenorhabditis elegans

Predicted to enable RNA polymerase II CTD heptapeptide repeat phosphatase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human RPAP2 (RNA polymerase II associated protein 2).

crn-6

Caenorhabditis elegans

Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Is an ortholog of human DNASE2B (deoxyribonuclease 2 beta).

ceh-1

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in DVC; lateral ganglion; and seam cell. Is an ortholog of human NKX1-1 (NK1 homeobox 1) and NKX1-2 (NK1 homeobox 2).

efl-2

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Expressed in dorsal nerve cord; head muscle; intestine; spermatheca; and ventral nerve cord. Is an ortholog of human E2F6 (E2F transcription factor 6).

aman-2

Caenorhabditis elegans

Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Located in Golgi apparatus. Expressed in head; pharynx; and ventral nerve cord. Is an ortholog of human MAN2A2 (mannosidase alpha class 2A member 2).