gmd-2

Caenorhabditis elegans

Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process and GDP-mannose metabolic process. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in open-angle glaucoma. Is an ortholog of human GMDS (GDP-mannose 4,6-dehydratase).

rhi-1

Caenorhabditis elegans

Predicted to enable Rho GDP-dissociation inhibitor activity. Predicted to be involved in Rho protein signal transduction. Located in cytosol and membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Is an ortholog of human ARHGDIA (Rho GDP dissociation inhibitor alpha); ARHGDIB (Rho GDP dissociation inhibitor beta); and ARHGDIG (Rho GDP dissociation inhibitor gamma).

ger-1

Caenorhabditis elegans

Enables GDP-L-fucose synthase activity. Involved in GDP-L-fucose biosynthetic process. Expressed in pharynx; seam cell; and spermatheca. Is an ortholog of human GFUS (GDP-L-fucose synthase).

bre-1

Caenorhabditis elegans

Enables GDP-mannose 4,6-dehydratase activity. Involved in GDP-L-fucose biosynthetic process; GDP-mannose metabolic process; and response to toxic substance. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Human ortholog(s) of this gene implicated in open-angle glaucoma. Is an ortholog of human GMDS (GDP-mannose 4,6-dehydratase).

mcp-1

Caenorhabditis elegans

Enables GDP-D-glucose phosphorylase activity. Involved in glucose metabolic process. Located in cytoplasm. Expressed in anterior hypodermis; nervous system; reproductive system; and spermatheca. Is an ortholog of human GDPGP1 (GDP-D-glucose phosphorylase 1).

uda-1

Caenorhabditis elegans

Enables GDP phosphatase activity and UDP phosphatase activity. Involved in GDP metabolic process and UDP metabolic process. Located in cytoplasmic vesicle membrane. Is an ortholog of human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)) and ENTPD6 (ectonucleoside triphosphate diphosphohydrolase 6).

gdi-1

Caenorhabditis elegans

Predicted to enable Rab GDP-dissociation inhibitor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in Down syndrome; non-syndromic X-linked intellectual disability 41; and psychotic disorder. Is an ortholog of human GDI1 (GDP dissociation inhibitor 1) and GDI2 (GDP dissociation inhibitor 2).

nstp-10

Caenorhabditis elegans

Predicted to enable GDP-fucose transmembrane transporter activity and antiporter activity. Predicted to be involved in GDP-fucose import into Golgi lumen and protein O-linked fucosylation. Predicted to be located in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIc. Is an ortholog of human SLC35C1 (solute carrier family 35 member C1).

sucg-1

Caenorhabditis elegans

Predicted to enable succinate-CoA ligase (GDP-forming) activity. Predicted to be involved in succinyl-CoA metabolic process and tricarboxylic acid cycle. Predicted to be located in mitochondrion. Predicted to be part of succinate-CoA ligase complex. Is an ortholog of human SUCLG2 (succinate-CoA ligase GDP-forming subunit beta).

C26D10.4

Caenorhabditis elegans

Predicted to enable fucokinase activity. Predicted to be involved in GDP-L-fucose salvage. Is an ortholog of human FCSK (fucose kinase).