gcs-1

Caenorhabditis elegans

Predicted to enable glutamate-cysteine ligase activity. Involved in glutathione biosynthetic process; response to arsenic-containing substance; and response to stress. Predicted to be part of glutamate-cysteine ligase complex. Expressed in ASIL; ASIR; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including colorectal cancer; cystic fibrosis; and glutamate-cysteine ligase deficiency. Is an ortholog of human GCLC (glutamate-cysteine ligase catalytic subunit).

E01A2.1

Caenorhabditis elegans

Predicted to enable enzyme regulator activity. Predicted to be involved in glutathione biosynthetic process. Predicted to be part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Is an ortholog of human GCLM (glutamate-cysteine ligase modifier subunit).

prdx-2

Caenorhabditis elegans

Enables thioredoxin peroxidase activity. Involved in several processes, including determination of adult lifespan; positive regulation of brood size; and response to stress. Located in cytoplasm. Expressed in body wall musculature; corpus; gonad; head; and tail. Human ortholog(s) of this gene implicated in colorectal cancer; methylmalonic aciduria and homocystinuria type cblC; and oral squamous cell carcinoma. Is an ortholog of human PRDX1 (peroxiredoxin 1) and PRDX2 (peroxiredoxin 2).