seg-2

Caenorhabditis elegans

seg-1

Caenorhabditis elegans

gas-2

Caenorhabditis elegans

nduf-2.2

Caenorhabditis elegans

Predicted to enable NAD binding activity; oxidoreductase activity, acting on NAD(P)H; and quinone binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be part of respiratory chain complex I. Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Is an ortholog of human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2).

gas-1

Caenorhabditis elegans

Predicted to enable NADH dehydrogenase (ubiquinone) activity and small molecule binding activity. Involved in mitochondrial electron transport, NADH to ubiquinone and response to xenobiotic stimulus. Located in intracellular membrane-bounded organelle. Expressed in anterior gonad arm; body wall musculature; nervous system; non-striated muscle; and tail. Used to study alcohol use disorder and mitochondrial complex I deficiency. Human ortholog(s) of this gene implicated in several diseases, including Leigh disease; multiple sclerosis; and nuclear type mitochondrial complex I deficiency 6. Is an ortholog of human NDUFS2 (NADH:ubiquinone oxidoreductase core subunit S2).

gsnl-1

Caenorhabditis elegans

Enables actin filament binding activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in actin filament-based process and regulation of cellular component organization. Located in actin cytoskeleton and striated muscle dense body. Expressed in hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Finnish type amyloidosis; artery disease (multiple); and gas gangrene. Is an ortholog of human CAPG (capping actin protein, gelsolin like).

rtr-1

Caenorhabditis elegans

cchl-1

Caenorhabditis elegans

Predicted to enable holocytochrome-c synthase activity. Located in mitochondrion. Human ortholog(s) of this gene implicated in linear skin defects with multiple congenital anomalies 1 and microphthalmia. Is an ortholog of human HCCS (holocytochrome c synthase).

clec-122

Caenorhabditis elegans

Is affected by several genes including pmk-1; glh-4; and glh-1 based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: C-type lectin-like/link domain superfamily; T-complex protein 10, C-terminal domain superfamily; C-type lectin-like; and C-type lectin fold.

clec-9

Caenorhabditis elegans

Is affected by several genes including etr-1; ash-2; and prg-1 based on tiling array; microarray; and RNA-seq studies. Is affected by twenty-three chemicals including aldicarb; tryptophan; and 1-methylnicotinamide based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: CUB domain; Snake venom C-type lectin-like; C-type lectin-like/link domain superfamily; Lectin C-type domain; Spermadhesin, CUB domain superfamily; C-type lectin-like; and C-type lectin fold.