gad-1

Caenorhabditis elegans

Involved in cell migration involved in gastrulation; establishment of mitotic spindle orientation; and regulation of mitotic cell cycle. Predicted to be located in nucleus and site of double-strand break. Expressed in germ line. Is an ortholog of human WDR70 (WD repeat domain 70).

unc-30

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in neuron differentiation; positive regulation of transcription by RNA polymerase II; and regulation of locomotion. Located in nucleus. Expressed in GABAergic neurons; ganglia; intestine; and ventral cord neurons. Human ortholog(s) of this gene implicated in Arts syndrome; clubfoot; and eye disease (multiple). Is an ortholog of human PITX2 (paired like homeodomain 2) and PITX3 (paired like homeodomain 3).

unc-25

Caenorhabditis elegans

Predicted to enable glutamate decarboxylase activity and pyridoxal phosphate binding activity. Involved in GABAergic synaptic transmission. Located in axon; perikaryon; and synapse. Expressed in EF neuron and neurons. Used to study alcohol use disorder; epilepsy; and spastic cerebral palsy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; amphetamine abuse; and diabetes mellitus (multiple). Is an ortholog of human GAD1 (glutamate decarboxylase 1) and GAD2 (glutamate decarboxylase 2).