fos-1

Caenorhabditis elegans

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and identical protein binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of stress response to copper ion; and regulation of gene expression. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including gonad; neurons; uterine pi cell; ventral uterine precursor; and vulval cell.

kreg-1

Caenorhabditis elegans

Involved in stress response to copper ion.

jun-1

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).

vab-10

Caenorhabditis elegans

Predicted to enable actin filament binding activity and structural molecule activity. Involved in epidermis morphogenesis. Located in apical plasma membrane; basal plasma membrane; and hemidesmosome. Expressed in several structures, including gonad; intestinal lumen; nerve ring; pharynx; and vulval cell. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex; hereditary sensory and autonomic neuropathy type 6; and lissencephaly 9 with complex brainstem malformation. Is an ortholog of human DST (dystonin).

aff-1

Caenorhabditis elegans

Involved in regulation of egg-laying behavior and syncytium formation by plasma membrane fusion. Located in plasma membrane. Expressed in anchor cell; egg-laying apparatus; epithelial cell; neurons; and pharyngeal muscle cell.

cash-1

Caenorhabditis elegans

Predicted to enable calmodulin binding activity. Involved in epithelial tube morphogenesis; positive regulation of endocytic recycling; and regulation of Golgi organization. Predicted to be located in protein-containing complex. Is an ortholog of human STRN3 (striatin 3).

egl-13

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell fate commitment; regulation of DNA-templated transcription; and vulval development. Located in nucleus. Expressed in several structures, including developing hermaphrodite gonad; egg-laying apparatus; intestinal cell; neurons; and uterine pi cell. Human ortholog(s) of this gene implicated in high grade glioma. Is an ortholog of human SOX13 (SRY-box transcription factor 13); SOX5 (SRY-box transcription factor 5); and SOX6 (SRY-box transcription factor 6).

pat-12

Caenorhabditis elegans

Involved in embryonic morphogenesis and hemidesmosome assembly. Located in hemidesmosome. Expressed in head neurons; mechanosensory neurons; rectum; seam cell; and spermatheca.

zmp-1

Caenorhabditis elegans

Enables metallopeptidase activity. Involved in basement membrane disassembly. Located in cell surface. Expressed in several structures, including P6.paal; P6.paar; P6.papl; gonad; and vulval cell. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Is an ortholog of human MMP15 (matrix metallopeptidase 15) and MMP24 (matrix metallopeptidase 24).