exc-1

Caenorhabditis elegans

Predicted to enable GTP binding activity. Involved in epithelial cell development and regulation of tube size. Predicted to be located in membrane. Expressed in amphid sheath cell and excretory canal.

exc-9

Caenorhabditis elegans

Predicted to enable zinc ion binding activity. Involved in anatomical structure morphogenesis; epithelial cell development; and regulation of tube size. Located in cytoplasm. Expressed in several structures, including ALM; distal tip cell; excretory canal; lumbar ganglion; and nerve ring. Is an ortholog of human CRIP1 (cysteine rich protein 1).

exc-7

Caenorhabditis elegans

Enables single-stranded RNA binding activity. Involved in several processes, including epithelial cell development; regulation of alternative mRNA splicing, via spliceosome; and regulation of neuron differentiation. Located in nuclear speck. Expressed in several structures, including excretory cell; neurons; somatic nervous system; tail; and vulva. Is an ortholog of human ELAVL4 (ELAV like RNA binding protein 4).

Y47D7A.18

Caenorhabditis elegans

Is affected by several genes including exc-7; csr-1; and rrf-3 based on RNA-seq and microarray studies. Is affected by allantoin based on microarray studies.

F56D6.9

Caenorhabditis elegans

Is affected by several genes including exc-7; nuo-6; and ptl-1 based on microarray and RNA-seq studies. Is affected by sixteen chemicals including rotenone; Tunicamycin; and indole based on RNA-seq and microarray studies.

exc-8

Caenorhabditis elegans

Acts upstream of or within epithelial cell development and regulation of tube size.

Y47D7A.7

Caenorhabditis elegans

Is affected by several genes including cyc-1; exc-7; and swsn-1 based on microarray and RNA-seq studies. Is affected by ten chemicals including methylmercury hydroxide; multi-walled carbon nanotube; and D-glucose based on RNA-seq and microarray studies.

exc-3

Caenorhabditis elegans

Acts upstream of or within epithelial cell development and regulation of tube size.

Y105C5B.7

Caenorhabditis elegans

Is affected by several genes including cyc-1; exc-7; and etr-1 based on microarray; tiling array; and RNA-seq studies. Is affected by eight chemicals including Heme; multi-walled carbon nanotube; and Alovudine based on microarray and RNA-seq studies.

exc-4

Caenorhabditis elegans

Predicted to enable chloride channel activity. Involved in epithelial cell development and regulation of tube size. Located in apical junction complex; apical plasma membrane; and lysosome. Expressed in several structures, including amphid sheath cell; excretory system; pharyngeal muscle cell; rectum; and vulva. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome and autosomal recessive nonsyndromic deafness 103. Is an ortholog of human CLIC2 (chloride intracellular channel 2) and CLIC4 (chloride intracellular channel 4).