nsy-1

Caenorhabditis elegans

Enables MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding activity; and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including determination of adult lifespan; positive regulation of macromolecule biosynthetic process; and response to stress. Located in axon cytoplasm; neuronal cell body; and postsynaptic density. Expressed in head; rectal gland cell; and tail. Used to study amphetamine abuse. Human ortholog(s) of this gene implicated in Huntington's disease and perinatal necrotizing enterocolitis. Is an ortholog of human MAP3K5 (mitogen-activated protein kinase kinase kinase 5).

mau-8

Caenorhabditis elegans

Expressed in body wall musculature; germ line; hypodermis; intestine; and pharynx. Is an ortholog of human PDC (phosducin) and PDCL (phosducin like).

Y48B6A.17

Caenorhabditis elegans

Is affected by several genes including puf-8; npr-8; and ins-11 based on RNA-seq studies. Is affected by paraquat based on RNA-seq studies.

set-8

Caenorhabditis elegans

Predicted to enable double-stranded DNA binding activity and histone methyltransferase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in nucleus.

Y49F6B.20

Caenorhabditis elegans

Is affected by nhr-8 based on RNA-seq studies.

F19B6.9

Caenorhabditis elegans

Is affected by npr-8 based on RNA-seq studies.

flp-8

Caenorhabditis elegans

Involved in negative regulation of turning behavior involved in mating. Predicted to be located in extracellular region. Expressed in PVM; head; nerve ring; and tail.

sma-8

Caenorhabditis elegans

him-8

Caenorhabditis elegans

Involved in meiotic chromosome segregation. Located in X chromosome; condensed nuclear chromosome; and nuclear envelope.

K08F8.15

Caenorhabditis elegans

Is affected by hda-2 and nhr-8 based on RNA-seq studies.