reps-1

Caenorhabditis elegans

Expressed in excretory secretory system; intestine; muscle cell; somatic nervous system; and vulva. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Is an ortholog of human REPS1 (RALBP1 associated Eps domain containing 1) and REPS2 (RALBP1 associated Eps domain containing 2). Human REPS1 enables SH3 domain binding activity.

eps-8

Caenorhabditis elegans

Enables actin filament binding activity. Involved in several processes, including anatomical structure morphogenesis; barbed-end actin filament capping; and supramolecular fiber organization. Located in apical part of cell; brush border; and hemidesmosome. Expressed in several structures, including P3.pa; P3.pp; P5.ppp; P7.paa; and P9.p. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102; autosomal recessive nonsyndromic deafness 106; and hypotrichosis 5. Is an ortholog of human EPS8L1 (EPS8 signaling adaptor L1).