Predicted to enable integrin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of cellular component organization; and regulation of locomotion. Located in several cellular components, including contractile muscle fiber; focal adhesion; and lateral plasma membrane. Part of integrin complex. Expressed in several structures, including GABAergic neurons; egg-laying apparatus; enteric muscle; gonad; and vulval precursor cell. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); blood platelet disease (multiple); and lung carcinoma (multiple). Is an ortholog of human ITGB1 (integrin subunit beta 1).
Predicted to be an extracellular matrix structural constituent. Involved in several processes, including basement membrane organization; generation of neurons; and response to stress. Located in basement membrane. Expressed in several structures, including anal depressor muscle; basal lamina; body wall musculature; egg-laying apparatus; and intestine. Human ortholog(s) of this gene implicated in familial nephrotic syndrome; junctional epidermolysis bullosa; and lung small cell carcinoma. Is an ortholog of human LAMA5 (laminin subunit alpha 5).